| Pair Name | Sanguinarium, Doxorubicin | ||
| Phytochemical Name | Sanguinarium (PubChem CID: 5154 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Sanguinarium, Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| MCR-5 | Healthy | Homo sapiens (Human) | CVCL_0440 | |
| Result | Cellular and molecular studies suggested adjuvant chemosensitizers SA and SN to reverse MDR in breast cancer cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle. Drug Dev Ind Pharm. 2024 Jan 5:1-15. doi: 10.1080/03639045.2024.2302557. | Click |
